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With the FA Cup final safely tucked under their belt, City will be pushing to secure a top-five place in the table to be assured of Champions League qualification next season.
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A win in this match will see Derby safe for another season. They have won their last two, and they will be hoping top scorer Jerry Yates scores again.
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Only one point separates Stoke and Derby, and neither are safe from the drop. When they met earlier in the season, Stoke won 2-1. But with both teams needing the points, a draw could be the outcome.
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With Marcus Rashford likely to be out for the rest of the season, Morgan Rogers will have to play in an advanced role, which should help his goal prospects.
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Villa are another team who are pushing for Champions League football next year. They are three points adrift with four to play, and they will be keen to wipe away their FA Cup semi-final disappointment.
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With both these teams already relegated, they will be playing for pride. Southampton will want to get at least one point to ensure they don't share the Premier League's lowest points with Derby. It should be a close game, but a home win.
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Ipswich come into this game already knowing their fate after a defeat at the weekend, whilst Everton will see their chance of a victory after two straight defeats.
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Arsenal are still in the Champions League and are yet to secure the runner-up spot. They will be seeking revenge against Bournemouth, who beat them 2-0 earlier in the season.
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Man U have had a terrible season, and it's only their Europa League exploits that have kept them alive. They will probably rest key players with the Europa semis in mind.
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Bruno Fernandes has been Man U's most outstanding player in a season that has been very disappointing. He is their top goal-getter, and he could score more here.
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Tottenham got off to a flying start against Liverpool but crumbled to a 5-1 defeat. They are safe but only two places above the relegation position. They could get a draw here.
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Newcastle's form of seven wins from their last eight matches has put them right in contention for a Champions League spot. They could pick up three points against an inconsistent Brighton.
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With the Premiership trophy securely stashed away at Anfield, Liverpool can finish the rest of the season off in style. But Chelsea will be desperate to spoil the party as they look for points to gain Champions League qualification.